![]() Dysregulation of PcG proteins can contribute to a number of human diseases, most notably, cancer ( Bracken and Helin, 2009 Margueron and Reinberg, 2011). Both PRC1 and PRC2 play a critical role in the maintenance of normal and cancer stem cell populations ( Ezhkova et al., 2009 Lukacs et al., 2010 Pietersen et al., 2008). ![]() ![]() PcG proteins form multiprotein repressive complexes called PRCs. Co.com, co.ru, co.net, co.org, co.de, co.jp, co.uk, co.br, co.pl, co.in, co.it, co.fr, co.au, co.info, co.nl, co.ir, co.cn, co.es, co.cz, co.ua, co.ca, co.kr, co.eu, co.biz, co.za, co.gr, co.co, co.ro, co.se, co.tw, co.vn, co.mx, co.tr, co.ch, co.hu, co.at, co.be, co.tv, co.dk, co.me, co.ar, co.sk, co.us, co.no, co.fi, co.id, co.xyz, co.cl, co.by, co.nz, co.ie, co.il, co.pt, co.kz, co.my, co.lt, co.io, co.hk, co.cc, co.sg, co.edu, co.pk, co.su, co.рф, co.bg, co.th, co.top, co.lv, co.hr, co.pe, co.rs, co.club, co.ae, co.si, co.az, co.ph, co.pro, co.ng, co.tk, co.ee, co.mobi, co.asia, co.ws, co.ve, co.pw, co.sa, co.gov, co.cat, co.nu, co.ma, co.lk, co.ge, co.tech, co.online, co.uz, co.is, co.fm, co.lu, co.am, co.bd, co.to, co.ke, co.name, co.uy, co.ec, co.ba, co.ml, co.site, co.do, co.website, co.mn, co.mk, co.ga, co.link, co.tn, co.md, co.travel, co.space, co.cf, co.pics, co.eg, co.im, co.bz, co.la, co.py, co.al, co.gt, co.np, co.tz, co.kg, co.cr, co.coop, co.today, co.qa, co.dz, co.tokyo, co.ly, co.bo, co.cy, co.news, co.li, co.ug, co.jobs, co.vc, co.click, co.pa, co.guru, co.sv, co.aero, co.work, co.gq, co.ag, co.jo, co.rocks, co.ps, co.kw, co.om, co.ninja, co.af, co.media, co.so, co.win, co.life, co.st, co.cm, co.mu, co.ovh, co.lb, co.tj, co.gh, co.ni, co.re, co.download, co.gg, co.kh, co.cu, co.ci, co.mt, co.ac, co.center, co.bh, co.hn, co.london, co.mo, co.tips, co.ms, co.press, co.agency, co.ai, co.sh, co.zw, co.rw, co.digital, co.one, co.sn, co.science, co.sy, co.red, co.nyc, co.sd, co.tt, co.moe, co.world, co.iq, co.zone, co.mg, co.academy, co.mm, co.eus, co.gs, co.global, co.int, co.sc, co.company, co.cx, co.video, co.as, co.ad, co.bid, co.moscow, co.na, co.tc, co.design, co.mz, co.wiki, co.trade, co.bn, co.wang, co.paris, co.solutions, co.zm, co.city, co.social, co.bt, co.ao, co.lol, co.expert, co.fo, co.live, co.host, co.sx, co.marketing, co.education, co.gl, co.bw, co.berlin, co.blue, co.cd, co.kim, co.land, co.directory, co.nc, co.guide, co.mil, co.pf, co.network, co.pm, co.bm, co.events, co.email, co.porn, co.buzz, co.mv, co.party, co.works, co.bike, co.gi, co.webcam, co.gal, co.systems, co.ht, co.report, co.et, co.pink, co.sm, co.jm, co.review, co.tm, co.ky, co.pg, co.pr, co.tools, co.bf, co.je, co.tl, co.photos, co.pub, co.tf, co.cool, co.fj, co.reviews, co.support, co.watch, co.yt, co.date, co.technology, co.укр, co.mr, co.services, co.photography, co.vg, co.community, co.gd, co.lc, co.help, co.market, co.photo, co.codes, co.dj, co.mc, co.gallery, co.wtf, co.uno, co.bio, co.black, co.bzh, co.gratis, co.ink, co.mw, co.audio, co.plus, co.chat, co.domains, co.gy, co.ooo, co.tel, co.training, co.онлайн, co.deals, co.taipei, co.cash, co.gift, co.scot, co.sr, co.camp, co.cloud, co.house, co.vu, co.bi, co.careers, co.team, co.istanbul, co.museum, co.love, co.москва, co.coffee, co.desi, co.menu, co.money, co.software, co.cv, co.hosting, co.wf, co.ye, co.care, co.direct, co.international, co.run, co.бел, co.church, co.gm, co.onl, co.ren, co.sl, co.vision, co.bar, co.cards, co.exchange, co.school, co.sz, co.bank, co.boutique, co.fit, co.kitchen, co.kiwi, co.ventures, co.amsterdam, co.bb, co.dm, co.style, co.brussels, co.clothing, co.dating, co.wien, co.bs, co.business, co.casino, co.pictures, co.ax, co.cricket, co.energy, co.estate, co.farm, co.gp, co.institute, co.nagoya, co.Polycomb group (PcG) proteins are evolutionarily conserved regulators of gene silencing important in metazoan development ( Surface et al.), stem cell pluripotency ( Pereira et al.), and X chromosome inactivation ( Cao et al., 2002 Margueron and Reinberg, 2011).
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